Synthetic vs Bioidentical Hormones

The Gajer Practice Blogs

December 7, 2023

The world of female hormones is a complex landscape that often leaves many puzzled. Understanding what’s beneficial, when it’s helpful, and for whom, alongside discerning the safety of hormone replacements, can indeed be perplexing. In this blog post, I aim to shed light on these queries.

Let’s embark on a journey into the realm of oral contraceptive pills, commonly known as birth control. While these pills have empowered women by granting autonomy over their reproductive choices, like any medication, they’re not devoid of risks. Our reproductive system inherently drives the urge for procreation, necessitating substantial doses of hormones to prevent pregnancy. Birth control pills contain estrogen and progesterone in quantities much higher than naturally found in women’s bodies, which presents a few concerns. Firstly, the presence of estrogen heightens the risk of blood clots, especially in women who smoke. Secondly, the elevated hormone doses prompt the increase of sex-hormone binding globulin (SHBG), responsible for disposing of excess hormones. Unfortunately, SHBG doesn’t discriminate and also binds free circulating thyroid hormones and testosterone. In terms of safety, intrauterine devices (IUDs) stand out as the most reliable forms of birth control, such as the non-hormonal copper IUD or the progestin-secreting Mirena. If an IUD isn’t preferred, alternatives like the NuvaRing or low-dose birth control pills are considered safer options.

Moving on, let’s delve into hormone replacement therapy for managing menopausal symptoms. Mainstream treatments like Provera (a synthetic progestin), Premarin (conjugated estrogen), and Prempro (a combination of synthetic progestin and conjugated estrogen) exist, but they come with their share of issues. These treatments elevate SHBG levels and deplete the body of its natural hormones. Premarin, derived from horse urine in the 1930s, initially seemed promising but later revealed its stark dissimilarity to human hormones, significantly increasing the risks of cancer, heart disease, and blood clots. Similarly, Provera, though developed as a solution to reduce endometrial cancer risks in women on estrogen, poses its own set of side effects including anxiety, depression, bone loss, and increased risks of blood clots, heart disease, stroke, and breast cancer.

Thankfully, bioidentical hormones have emerged as a viable alternative. These hormones are identical to those naturally produced by our bodies and have been demonstrated in numerous studies to promote overall health while mitigating risks of heart disease, blood clots, and cancer. Bioidentical hormone therapy focuses on harmonizing and balancing hormones to achieve optimal levels that foster holistic health and wellbeing. If you’re considering hormone evaluation, you can find more information here.

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